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Understanding Marginal Structural Models for Time-Varying Exposures: Pitfalls and Tips
Authors
Tomohiro Shinozaki, Etsuji Suzuki
J-Stage
https://www.jstage.jst.go.jp/article/jea/30/9/30_JE20200226/_article
PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7429147/
Highlights
- Marginal structural models (MSMs) should be distinguished from inverse probability weighting.
- MSM shows prespecified assumptions on causal estimands, while an exposure probability model is an imposed restriction on observed distribution.
- As MSM and exposure probability model are used for different purposes, misspecification of these models would lead to biases in different ways.
- Model specifications of MSMs and exposure probability models raise different challenges in real data analysis.
- G-formula, which shares identifiability assumptions with inverse probability weighting, can be used to fit MSMs only when the models are saturated.