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BMI and cardiometabolic traits in Japanese: a Mendelian randomization study
Authors
Mako Nagayoshi, Asahi Hishida, Tomonori Shimizu, Yasufumi Kato, Yoko Kubo, Rieko Okada, Takashi Tamura, Jun Otonari, Hiroaki Ikezaki, Megumi Hara, Yuichiro Nishida, Isao Oze, Yuriko N. Koyanagi, Yohko Nakamura, Miho Kusakabe, Rie Ibusuki, Keiichi Shibuya, Sadao Suzuki, Takeshi Nishiyama, Teruhide Koyama, Etsuko Ozaki, Kiyonori Kuriki, Naoyuki Takashima, Yasuyuki Nakamura, Sakurako Katsuura-Kamano, Kokichi Arisawa, Masahiro Nakatochi, Yukihide Momozawa, Kenji Takeuchi, Kenji Wakai
J-Stage
https://www.jstage.jst.go.jp/article/jea/34/2/34_JE20220154/_article
PMC
https://pmc.ncbi.nlm.nih.gov/articles/PMC10751192/
Highlights
- The causal relationships between body mass index (BMI) and cardiometabolic traits in Japanese were assessed using the Mendelian randomization (MR) approach in a sample of 14,083 Japanese.
- In individual-level MR analyses, predicted BMI was not significantly associated with any cardiovascular traits in the Japanese population.
- Sensitivity analyses based on two-sample MR analyses of 173,430 Japanese subjects showed that BMI is associated with a variety of cardiometabolic traits.
- Even among the Japanese, an East Asian population with low levels of obesity, higher BMI could be causally associated with a variety of cardiometabolic traits, in line with the results of European studies.
- The causality of these associations should be clarified in future studies with larger populations.
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