PMC

https://pmc.ncbi.nlm.nih.gov/articles/PMC11637814/

Highlights

• We employ disease-mediating mortality separating disease-specific mortality into disease (the mediator) and mortality (the outcome) to characterize the natural course of hepatitis C virus (HCV).
• We identified three liver diseases (eg, liver cirrhosis, liver cancer) and nine non-liver diseases (eg, septicemia, renal diseases, endocrine diseases, hypertension) that mediate HCV-induced mortality and provide the proportion of mediation to reflect their relative contributions.
• For developing countries with limited access to direct-acting antiviral agents, our study may guide health policies in screening for particular diseases (except liver diseases) to reduce the preventable deaths of the HCV-infected population.

Selected Result