Editors’ Picks
Metabolomics Profiles Alterations in Cigarette Smokers and Heated Tobacco Product Users
Authors
Sei Harada, Hideki Ohmomo, Minako Matsumoto, Mizuki Sata, Miho Iida, Aya Hirata, Naoko Miyagawa, Kazuyo Kuwabara, Suzuka Kato, Ryota Toki, Shun Edagawa, Daisuke Sugiyama, Asako Sato, Akiyoshi Hirayama, Masahiro Sugimoto, Tomoyoshi Soga, Masaru Tomita, Atsushi Shimizu, Tomonori Okamura, Toru Takebayashi
J-Stage
Highlights
- Metabolomics study of over 9,900 Japanese participants reveals distinct metabolite profiles in cigarette smokers compared to never smokers.
- Heated tobacco product (HTP) users showed metabolite profiles closer to cigarette smokers than never smokers, indicating similar health risks.
- Biomarkers involved in glutamate (Glu) metabolism were associated with both cigarette smoking and HTP use.
- Glu pathway activation in smokers and HTP users may contribute to cardiovascular diseases, supporting the link between smoking and atherosclerosis.
- Findings suggest the need for further studies to assess the long-term cardiovascular disease risks of HTP use and develop effective risk assessment strategies.
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